Ontology highlight
ABSTRACT:
SUBMITTER: Martin R
PROVIDER: S-EPMC2630677 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Martin Raquel R Smibert Peter P Yalcin Abdullah A Tyler David M DM Schäfer Ulrich U Tuschl Thomas T Lai Eric C EC
Molecular and cellular biology 20081201 3
Canonical primary microRNA (miRNA) transcripts and mirtrons are proposed to transit distinct nuclear pathways en route to generating mature approximately 22 nucleotide regulatory RNAs. We generated a null allele of Drosophila pasha, which encodes a double-stranded RNA-binding protein partner of the RNase III enzyme Drosha. Analysis of this mutant yielded stringent evidence that Pasha is essential for the biogenesis of canonical miRNAs but is dispensable for the processing and function of mirtron ...[more]