Ontology highlight
ABSTRACT:
SUBMITTER: Berezikov E
PROVIDER: S-EPMC2763384 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Berezikov Eugene E Chung Wei-Jen WJ Willis Jason J Cuppen Edwin E Lai Eric C EC
Molecular cell 20071001 2
Mirtrons are alternative precursors for microRNA biogenesis that were recently described in invertebrates. These short hairpin introns use splicing to bypass Drosha cleavage, which is otherwise essential for the generation of canonical animal microRNAs. Using computational and experimental strategies, we now establish that mammals have mirtrons as well. We identified 3 mirtrons that are well conserved and expressed in diverse mammals, 16 primate-specific mirtrons, and 46 candidates supported by ...[more]