Ontology highlight
ABSTRACT:
SUBMITTER: Okamura K
PROVIDER: S-EPMC2729315 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Okamura Katsutomo K Hagen Joshua W JW Duan Hong H Tyler David M DM Lai Eric C EC
Cell 20070628 1
The canonical microRNA (miRNA) pathway converts primary hairpin precursor transcripts into approximately 22 nucleotide regulatory RNAs via consecutive cleavages by two RNase III enzymes, Drosha and Dicer. In this study, we characterize Drosophila small RNAs that derive from short intronic hairpins termed "mirtrons." Their nuclear biogenesis appears to bypass Drosha cleavage, which is essential for miRNA biogenesis. Instead, mirtron hairpins are defined by the action of the splicing machinery and ...[more]