Towards the total chemical synthesis of integral membrane proteins: a general method for the synthesis of hydrophobic peptide-thioester building blocks.

ABSTRACT: Modification of a peptide-(?)thioester with a sequence of six arginines on the thioester leaving group can render soluble all peptides derived from a polytopic integral membrane protein. This strategy greatly simplifies the synthesis of peptide-(?)thioester building blocks for the total chemical synthesis of integral membrane proteins by native chemical ligation.

SUBMITTER: Johnson EC 

PROVIDER: S-EPMC2631171 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature