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ABSTRACT:
SUBMITTER: Richter JM
PROVIDER: S-EPMC2634302 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20081201 52
Full details are provided for the total synthesis of several members of the hapalindole family of natural products, including hapalindole Q, 12-epi-hapalindole D, 12-epi-fischerindole U, 12-epi-fischerindole G, 12-epi-fischerindole I, and welwitindolinone A. Use of the recently developed direct indole coupling enabled an efficient, practical, scalable, and protecting-group-free synthesis of each of these natural products. The original biosynthetic proposal is reviewed, and a revised biosynthetic ...[more]