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Enantiospecific total synthesis of N-methylwelwitindolinone D isonitrile.

ABSTRACT: The total synthesis of N-methylwelwitindolinone?D isonitrile (1) has been achieved in 17 steps from a readily available carvone derivative. The route features a double C-H functionalization event involving a keto oxindole substrate to introduce the tetrahydrofuran ring of the natural product.

SUBMITTER: Styduhar ED 

PROVIDER: S-EPMC3892424 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Enantiospecific total synthesis of N-methylwelwitindolinone D isonitrile.

Styduhar Evan D ED   Huters Alexander D AD   Weires Nicholas A NA   Garg Neil K NK  

Angewandte Chemie (International ed. in English) 20131002 47

The total synthesis of N-methylwelwitindolinone D isonitrile (1) has been achieved in 17 steps from a readily available carvone derivative. The route features a double C-H functionalization event involving a keto oxindole substrate to introduce the tetrahydrofuran ring of the natural product. ...[more]

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