Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC2636702 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Seminars in cancer biology 20081002 6
Covalent conjugation of proteins with ubiquitin is one the most important post-translational modifications because it controls intracellular protein trafficking typically resulting in protein degradation. Frequently ubiquitinated proteins are targeted to the proteasome for degradation in the cytosol. However, ubiquitinated membrane bound proteins can also be targeted for endocytosis and degradation in the lysosome. Ubiquitin-dependent degradation pathways have clear cancer relevance due to their ...[more]