Ontology highlight
ABSTRACT:
SUBMITTER: Holt LJ
PROVIDER: S-EPMC2636747 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Holt Liam J LJ Krutchinsky Andrew N AN Morgan David O DO
Nature 20080615 7202
At the onset of anaphase, sister-chromatid cohesion is dissolved abruptly and irreversibly, ensuring that all chromosome pairs disjoin almost simultaneously. The regulatory mechanisms that generate this switch-like behaviour are unclear. Anaphase is initiated when a ubiquitin ligase, the anaphase-promoting complex (APC), triggers the destruction of securin, thereby allowing separase, a protease, to disrupt sister-chromatid cohesion. Here we demonstrate that the cyclin-dependent kinase 1 (Cdk1)-d ...[more]