Ontology highlight
ABSTRACT:
SUBMITTER: Labeit D
PROVIDER: S-EPMC263879 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Labeit Dietmar D Watanabe Kaori K Witt Christian C Fujita Hideaki H Wu Yiming Y Lahmers Sunshine S Funck Theodor T Labeit Siegfried S Granzier Henk H
Proceedings of the National Academy of Sciences of the United States of America 20031030 23
Titin (also known as connectin) is a giant protein with a wide range of cellular functions, including providing muscle cells with elasticity. Its physiological extension is largely derived from the PEVK segment, rich in proline (P), glutamate (E), valine (V), and lysine (K) residues. We studied recombinant PEVK molecules containing the two conserved elements: approximately 28-residue PEVK repeats and E-rich motifs. Single molecule experiments revealed that calcium-induced conformational changes ...[more]