The giant protein titin: a regulatory node that integrates myocyte signaling pathways.
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ABSTRACT:
SUBMITTER: Kruger M
PROVIDER: S-EPMC3060543 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
The giant protein titin: a regulatory node that integrates myocyte signaling pathways.
Krüger Martina M Linke Wolfgang A WA
The Journal of biological chemistry 20110121 12
Titin, the largest protein in the human body, is well known as a molecular spring in muscle cells and scaffold protein aiding myofibrillar assembly. However, recent evidence has established another important role for titin: that of a regulatory node integrating, and perhaps coordinating, diverse signaling pathways, particularly in cardiomyocytes. We review key findings within this emerging field, including those related to phosphorylation of the titin springs, and also discuss how titin particip ...[more]
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