Ontology highlight
ABSTRACT:
SUBMITTER: Joshi PS
PROVIDER: S-EPMC2643370 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Joshi Pushkar S PS Molyneaux Bradley J BJ Feng Liang L Xie Xiaoling X Macklis Jeffrey D JD Gan Lin L
Neuron 20081001 2
While progenitor-restricted factors broadly specify area identities in developing neocortex, the downstream regulatory elements involved in acquisition of those identities in postmitotic neurons are largely unknown. Here, we identify Bhlhb5, a transcription factor expressed in layers II-V, as a postmitotic regulator of area identity. Bhlhb5 is initially expressed in a high caudomedial to low rostrolateral gradient that transforms into a sharp border between sensory and rostral motor cortices. Bh ...[more]