Ontology highlight
ABSTRACT:
SUBMITTER: Zembrzycki A
PROVIDER: S-EPMC4450391 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Zembrzycki Andreas A Perez-Garcia Carlos G CG Wang Chia-Fang CF Chou Shen-Ju SJ O'Leary Dennis D M DD
Proceedings of the National Academy of Sciences of the United States of America 20150513 21
Current knowledge suggests that cortical sensory area identity is controlled by transcription factors (TFs) that specify area features in progenitor cells and subsequently their progeny in a one-step process. However, how neurons acquire and maintain these features is unclear. We have used conditional inactivation restricted to postmitotic cortical neurons in mice to investigate the role of the TF LIM homeobox 2 (Lhx2) in this process and report that in conditional mutant cortices area patternin ...[more]