Unknown

Dataset Information

0

Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells.

ABSTRACT: A group of T cells recognizes glycolipids presented by molecules of the CD1 family. The CD1d-restricted natural killer T cells (NKT cells) are primarily considered to be self-reactive. By employing CD1d-binding and T cell assays, the following structural parameters for presentation by CD1d were defined for a number of mycobacterial and mammalian lipids: two acyl chains facilitated binding, and a polar head group was essential for T cell recognition. Of the mycobacterial lipids tested, only a phosphatidylinositol mannoside (PIM) fulfilled the requirements for CD1d binding and NKT cell stimulation. This PIM activated human and murine NKT cells via CD1d, thereby triggering antigen-specific IFN-gamma production and cell-mediated cytotoxicity, and PIM-loaded CD1d tetramers identified a subpopulation of murine and human NKT cells. This phospholipid, therefore, represents a mycobacterial antigen recognized by T cells in the context of CD1d.

SUBMITTER: Fischer K 

PROVIDER: S-EPMC489995 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells.

Fischer Karsten K   Scotet Emmanuel E   Niemeyer Marcus M   Koebernick Heidrun H   Zerrahn Jens J   Maillet Sophie S   Hurwitz Robert R   Kursar Mischo M   Bonneville Marc M   Kaufmann Stefan H E SH   Schaible Ulrich E UE  

Proceedings of the National Academy of Sciences of the United States of America 20040708 29

A group of T cells recognizes glycolipids presented by molecules of the CD1 family. The CD1d-restricted natural killer T cells (NKT cells) are primarily considered to be self-reactive. By employing CD1d-binding and T cell assays, the following structural parameters for presentation by CD1d were defined for a number of mycobacterial and mammalian lipids: two acyl chains facilitated binding, and a polar head group was essential for T cell recognition. Of the mycobacterial lipids tested, only a pho  ...[more]

Similar Datasets

Unknown Mycobacterial phosphatidylinositol mannoside 6 (PIM6) up-regulates TCR-triggered HIV-1 replication in CD4+ T cells.
| S-EPMC3839890 | biostudies-literature
Unknown Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells.
| S-EPMC2644137 | biostudies-literature
Unknown Recognition of CD1d-restricted antigens by natural killer T cells.
| S-EPMC3740582 | biostudies-literature
Unknown A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells.
| S-EPMC3064745 | biostudies-literature
Unknown Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells.
| S-EPMC3581944 | biostudies-literature
Unknown Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.
| S-EPMC7249499 | biostudies-literature
Unknown Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells.
| S-EPMC3471380 | biostudies-literature
Unknown dysregulation of CD1d-restricted type ii natural killer T cells leads to spontaneous development of colitis in mice.
| S-EPMC3267843 | biostudies-literature
Unknown V?2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen.
| S-EPMC3223435 | biostudies-literature
Unknown Cardiolipin binds to CD1d and stimulates CD1d-restricted γδ T cells in the normal murine repertoire.
| S-EPMC3076096 | biostudies-literature