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Synthesis of 5- and 6-carboxy-X-rhodamines.

ABSTRACT: An efficient route is reported to 5- and 6-carboxy-X-rhodamines (compounds 1 and 2) that contain multiple n-propylene or gamma,gamma-dimethylpropylene groups bridging terminal nitrogen atoms and the central xanthene core. Gram quantities of these dyes are synthesized from inexpensive starting materials. The isolated products are activated by selective transformation of the carboxylic acid group into N-hydroxysuccinimidyl esters in situ and then conjugated with an amino group of a molecule of interest.

SUBMITTER: Uddin MJ

PROVIDER: S-EPMC2646678 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Synthesis of 5- and 6-carboxy-X-rhodamines.

Uddin Md Jashim MJ Marnett Lawrence J LJ

Organic letters 20081007 21

An efficient route is reported to 5- and 6-carboxy-X-rhodamines (compounds 1 and 2) that contain multiple n-propylene or gamma,gamma-dimethylpropylene groups bridging terminal nitrogen atoms and the central xanthene core. Gram quantities of these dyes are synthesized from inexpensive starting materials. The isolated products are activated by selective transformation of the carboxylic acid group into N-hydroxysuccinimidyl esters in situ and then conjugated with an amino group of a molecule of int ...[more]

PMID: 18837556

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