Ontology highlight
ABSTRACT:
SUBMITTER: Tyner JW
PROVIDER: S-EPMC2647674 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Tyner Jeffrey W JW Erickson Heidi H Deininger Michael W N MW Willis Stephanie G SG Eide Christopher A CA Levine Ross L RL Heinrich Michael C MC Gattermann Norbert N Gilliland D Gary DG Druker Brian J BJ Loriaux Marc M MM
Blood 20081215 8
Transforming mutations in NRAS and KRAS are thought to play a causative role in the development of numerous cancers, including myeloid malignancies. Although mutations at amino acids 12, 13, or 61 account for the majority of oncogenic Ras variants, we hypothesized that less frequent mutations at alternate residues may account for disease in some patients with cancer of unexplained genetic etiology. To search for additional, novel RAS mutations, we sequenced all coding exons in NRAS, KRAS, and HR ...[more]