Ontology highlight
ABSTRACT:
SUBMITTER: Kortum KM
PROVIDER: S-EPMC5524534 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kortüm K Martin KM Mai Elias K EK Hanafiah Nur H NH Shi Chang-Xi CX Zhu Yuan-Xiao YX Bruins Laura L Barrio Santiago S Jedlowski Patrick P Merz Maximilian M Xu Jing J Stewart Robert A RA Andrulis Mindaugas M Jauch Anna A Hillengass Jens J Goldschmidt Hartmut H Bergsagel P Leif PL Braggio Esteban E Stewart A Keith AK Raab Marc S MS
Blood 20160725 9
In this study, targeted sequencing to screen 50 multidrug refractory multiple myeloma (rMM) patients was performed by using the Multiple Myeloma Mutation Panel. Patients were pretreated with both immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs), and 88%, 78%, and 68% were refractory to an IMiD, a PI, or both, respectively. The majority of patients had progressive (82%) or refractory (78%) disease immediately before sampling, with 43% being IMiD refractory and 46% being PI refractor ...[more]