Ontology highlight
ABSTRACT:
SUBMITTER: Richard D
PROVIDER: S-EPMC2648313 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Richard Dave D Kats Lev M LM Langer Christine C Black Casilda G CG Mitri Khosse K Boddey Justin A JA Cowman Alan F AF Coppel Ross L RL
PLoS pathogens 20090306 3
The rhoptry of the malaria parasite Plasmodium falciparum is an unusual secretory organelle that is thought to be related to secretory lysosomes in higher eukaryotes. Rhoptries contain an extensive collection of proteins that participate in host cell invasion and in the formation of the parasitophorous vacuole, but little is known about sorting signals required for rhoptry protein targeting. Using green fluorescent protein chimeras and in vitro pull-down assays, we performed an analysis of the s ...[more]