Ontology highlight
ABSTRACT:
SUBMITTER: Maestre L
PROVIDER: S-EPMC2649342 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Haematologica 20090127 3
The transcription factor XBP1 (X-box-binding protein 1) is essential for plasma cell (PC) differentiation and immunoglobulin secretion. XBP1 is widely expressed, but its activity is precisely controlled by mRNA splicing in response to endoplasmic reticulum (ER) stress. It is the active form of XBP1, XBP1(S), which is required for PC differentiation. The relationship between XBP1(S) expression and PC differentiation in human tissue and its expression in hematologic malignancies has eluded assessm ...[more]