Ontology highlight
ABSTRACT:
SUBMITTER: Apoorva F
PROVIDER: S-EPMC5965297 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Apoorva F F Loiben Alexander M AM Shah Shivem B SB Purwada Alberto A Fontan Lorena L Goldstein Rebecca R Kirby Brian J BJ Melnick Ari M AM Cosgrove Benjamin D BD Singh Ankur A
Cell reports 20180401 2
The role of microenvironment-mediated biophysical forces in human lymphomas remains elusive. Diffuse large B cell lymphomas (DLBCLs) are heterogeneous tumors, which originate from highly proliferative germinal center B cells. These tumors, their associated neo-vessels, and lymphatics presumably expose cells to particular fluid flow and survival signals. Here, we show that fluid flow enhances proliferation and modulates response of DLBCLs to specific therapeutic agents. Fluid flow upregulates sur ...[more]