Ontology highlight
ABSTRACT:
SUBMITTER: Burks SR
PROVIDER: S-EPMC2650013 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Burks Scott R SR Ni Jiahong J Muralidharan Sukumaran S Coop Andrew A Kao Joseph P Y JP Rosen Gerald M GM
Bioconjugate chemistry 20080911 10
Nitroxide-based electron paramagnetic resonance (EPR) imaging agents are useful quantitative probes of O2 concentration in vivo in real time. Lipophilic, labile alkanoyloxymethyl esters of nitroxides can cross the blood-brain barrier, and after hydrolysis, the corresponding anionic nitroxide is intracellularly entrapped at levels sufficient to permit O2 measurements. The utility of nitroxides as EPR imaging agents depends critically on their ability to accumulate in the brain to high levels. In ...[more]