Ontology highlight
ABSTRACT:
SUBMITTER: Roger T
PROVIDER: S-EPMC2650125 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Roger Thierry T Froidevaux Céline C Le Roy Didier D Reymond Marlies Knaup MK Chanson Anne-Laure AL Mauri Davide D Burns Kim K Riederer Beat Michel BM Akira Shizuo S Calandra Thierry T
Proceedings of the National Academy of Sciences of the United States of America 20090130 7
Toll-like receptor 4 (TLR4), the signal-transducing molecule of the LPS receptor complex, plays a fundamental role in the sensing of LPS from gram-negative bacteria. Activation of TLR4 signaling pathways by LPS is a critical upstream event in the pathogenesis of gram-negative sepsis, making TLR4 an attractive target for novel antisepsis therapy. To validate the concept of TLR4-targeted treatment strategies in gram-negative sepsis, we first showed that TLR4(-/-) and myeloid differentiation primar ...[more]