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CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.

ABSTRACT: Two CMY-2 derivatives, CMY-31 (Gln(215)-->Arg) from Salmonella enterica serotype Newport and CMY-36 (Ala(77)-->Cys and Gln(193)-->Glu) from Klebsiella pneumoniae, were characterized. Both cephalosporinases functionally resembled CMY-2. bla(CMY) alleles occurred as parts of a putative transposon comprising ISEcp1B and a Citrobacter freundii-derived sequence carried by ColE1-like plasmids similar to CMY-5-encoding pTKH11 from Klebsiella oxytoca.

SUBMITTER: Zioga A

PROVIDER: S-EPMC2650574 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature

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CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.

Zioga A A Whichard J M JM Kotsakis S D SD Tzouvelekis L S LS Tzelepi E E Miriagou V V

Antimicrobial agents and chemotherapy 20081222 3

Two CMY-2 derivatives, CMY-31 (Gln(215)-->Arg) from Salmonella enterica serotype Newport and CMY-36 (Ala(77)-->Cys and Gln(193)-->Glu) from Klebsiella pneumoniae, were characterized. Both cephalosporinases functionally resembled CMY-2. bla(CMY) alleles occurred as parts of a putative transposon comprising ISEcp1B and a Citrobacter freundii-derived sequence carried by ColE1-like plasmids similar to CMY-5-encoding pTKH11 from Klebsiella oxytoca. ...[more]

PMID: 19104021

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