Ontology highlight
ABSTRACT:
SUBMITTER: Leiper LJ
PROVIDER: S-EPMC2654056 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Leiper Lucy J LJ Ou Jingxing J Walczysko Petr P Kucerova Romana R Lavery Derek N DN West John D JD Collinson J Martin JM
Investigative ophthalmology & visual science 20081121 3
<h4>Purpose</h4>Corneal nerves play essential roles in maintaining the ocular surface through provision of neurotrophic support, but genetic control of corneal innervation is poorly understood. The possibility of a neurotrophic failure in ocular surface disease associated with heterozygosity at the Pax6 locus (aniridia-related keratopathy [ARK]) was investigated.<h4>Methods</h4>Patterns of corneal innervation were studied during development and aging in mice with different Pax6 dosages and in ch ...[more]