PAX6 dosage effects on corneal development, growth, and wound healing.
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ABSTRACT:
SUBMITTER: Dora N
PROVIDER: S-EPMC2655055 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
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PAX6 dosage effects on corneal development, growth, and wound healing.
Dorà Natalie N Ou Jingxing J Kucerova Romana R Parisi Ida I West John D JD Collinson J Martin JM
Developmental dynamics : an official publication of the American Association of Anatomists 20080501 5
The requirement for correct dosage of the transcription factor Pax6 during corneal growth and development was investigated using the Pax6-overexpressing (PAX77) transgenic mouse. Transgenics had a microcornea phenotype due to failure of postnatal growth, associated with reduction in the number of cells layers in the corneal epithelium. Cell cycle progression was monitored using bromodeoxyuridine, p63, cyclin E, and phosphohistone-3 labeling: proliferation rates were higher in PAX77+ than wild-ty ...[more]
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