Ontology highlight
ABSTRACT:
SUBMITTER: McElroy CA
PROVIDER: S-EPMC2654238 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
McElroy Craig A CA Dohm Julie A JA Walsh Scott T R ST
Structure (London, England : 1993) 20090101 1
IL-7 and IL-7Ralpha bind the gamma(c) receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. We report that the IL-7Ralpha ectodomain uses glycosylation to modulate its binding constants to IL-7, unlike the other receptors in the gamma(c) family. IL-7 binds glycosylated IL-7Ralpha 300-fold more tightly than unglycosylated IL-7Ralpha, and the enhanced affinity is attributed primarily to an accelerated on rate. Structural comp ...[more]