Ontology highlight
ABSTRACT:
SUBMITTER: Guillon N
PROVIDER: S-EPMC2654724 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Guillon Noëlle N Tirode Franck F Boeva Valentina V Zynovyev Andrei A Barillot Emmanuel E Delattre Olivier O
PloS one 20090323 3
The fusion between EWS and ETS family members is a key oncogenic event in Ewing tumors and important EWS-FLI1 target genes have been identified. However, until now, the search for EWS-FLI1 targets has been limited to promoter regions and no genome-wide comprehensive analysis of in vivo EWS-FLI1 binding sites has been undertaken. Using a ChIP-Seq approach to investigate EWS-FLI1-bound DNA sequences in two Ewing cell lines, we show that this chimeric transcription factor preferentially binds two t ...[more]