Ontology highlight
ABSTRACT:
SUBMITTER: Aqeilan RI
PROVIDER: S-EPMC2654736 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Aqeilan Rami I RI Hagan John P JP de Bruin Alain A Rawahneh Maysoon M Salah Zaidoun Z Gaudio Eugenio E Siddiqui Hasan H Volinia Stefano S Alder Hansjuerg H Lian Jane B JB Stein Gary S GS Croce Carlo M CM
Endocrinology 20081030 3
The WW domain-containing oxidoreductase (WWOX) gene encodes a 46-kDa tumor suppressor. The Wwox protein contains two N-terminal WW domains that interact with several transcriptional activators containing proline-tyrosine motifs and a central short-chain dehydrogenase/reductase domain that has been suggested to play a role in steroid metabolism. Recently, we have shown that targeted deletion of the Wwox gene in mice leads to postnatal lethality and defects in bone growth. Here, we report that Wwo ...[more]