Ontology highlight
ABSTRACT:
SUBMITTER: Saigo C
PROVIDER: S-EPMC6125347 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Saigo Chiemi C Kito Yusuke Y Takeuchi Tamotsu T
Frontiers in oncology 20180830
Recent findings indicate that the WW domain-containing oxidoreductase (WWOX) is a tumor suppressor protein that contains two N-terminal WW domains and a central short-chain dehydrogenase/reductase domain. WWOX protein mediates multiple signaling networks that suppress carcinogenesis through binding of its first WW domain to various cancer-associated proteins, i.e., p73, AP-2γ, and others. Although the tumor suppressor property of WWOX is inarguable, WWOX is not inactivated in the manner characte ...[more]