A novel class of allosteric modulators of AMPA/Kainate receptors.
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ABSTRACT:
SUBMITTER: Cannazza G
PROVIDER: S-EPMC2656388 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
A novel class of allosteric modulators of AMPA/Kainate receptors.
Cannazza Giuseppe G Jozwiak Krzysztof K Parenti Carlo C Braghiroli Daniela D Carrozzo Marina M MM Puia Giulia G Losi Gabriele G Losi Gabriele G Baraldi Mario M Lindner Wolfgang W Wainer Irving W IW
Bioorganic & medicinal chemistry letters 20081230 4
The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared. ...[more]
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