Ontology highlight
ABSTRACT:
SUBMITTER: Shao F
PROVIDER: S-EPMC2656649 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Shao Fangwei F Weissleder Ralph R Hilderbrand Scott A SA
Bioconjugate chemistry 20081201 12
A facile synthetic route to prepare monofunctional carbocyanine dyes for biological application is developed. Three pentamethine carbocyanine dyes have been successfully modified with a variety of functional groups such as: carboxylic acids, azides, or alkynes. The new dyes are characterized by strong NIR fluorescence emission, high extinction coefficients and good quantum yields. The azide and alkyne dyes have potential utility as components in bioorthogonal labeling schemes via [2 + 3] dipolar ...[more]