Ontology highlight
ABSTRACT:
SUBMITTER: Sinha SH
PROVIDER: S-EPMC4151304 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20120621
Protein arginine methylation regulates multiple biological processes. Deregulation of protein arginine methyltransferase (PRMT) activities has been observed in many disease phenotypes. Small molecule probes that target PRMTs with strong affinity and selectivity can be used as valuable tools to dissect biological mechanisms of arginine methylation and establish the role of PRMT proteins in a disease process. In this work, we report synthesis and evaluation of a class of carbocyanine compounds con ...[more]