Ontology highlight
ABSTRACT:
SUBMITTER: Westbrook R
PROVIDER: S-EPMC2657169 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Westbrook Reyhan R Bonkowski Michael S MS Bonkowski Michael S MS Strader April D AD Bartke Andrzej A
The journals of gerontology. Series A, Biological sciences and medical sciences 20090313 4
Growth hormone (GH) signaling influences longevity in mice, with decreased GH signaling associated with longer life span and increased GH signaling with shortened life span. A proposed mechanism through which GH signaling influences life span postulates that decreased GH signaling lowers metabolic rate, thus slowing aging by decreasing production of damaging free radicals. The influence of altered GH signaling on metabolism was tested by monitoring oxygen consumption (VO(2)), respiratory quotien ...[more]