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Transcription profiling of long-lived Ames dwarf mice investigating the loss of liver sexual dimorphism

ABSTRACT: Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice.

ORGANISM(S): Mus musculus

SUBMITTER: Susan Venable

PROVIDER: E-MEXP-347 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice.

Amador-Noguez Daniel D Zimmerman John J Venable Susan S Darlington Gretchen G

Biochemical and biophysical research communications 20050701 4

Genetic mutations that increase lifespan in mice frequently involve alterations in the growth hormone/insulin-like growth factor-I signaling pathway. Although several of the effects of GH on gene expression are known to be sex-dependent, an understanding of the gender-specific vs. gender-independent effects of lifespan-extending mutations of the GH/IGF-I axis is currently lacking. The Ames dwarf mice (prop1(df/df)) are GH, prolactin and thyroid-stimulating hormone deficient and exhibit an increa ...[more]

PMID: 15925325

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