Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Susan Venable
PROVIDER: E-MEXP-347 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Biochemical and biophysical research communications 20050701 4
Genetic mutations that increase lifespan in mice frequently involve alterations in the growth hormone/insulin-like growth factor-I signaling pathway. Although several of the effects of GH on gene expression are known to be sex-dependent, an understanding of the gender-specific vs. gender-independent effects of lifespan-extending mutations of the GH/IGF-I axis is currently lacking. The Ames dwarf mice (prop1(df/df)) are GH, prolactin and thyroid-stimulating hormone deficient and exhibit an increa ...[more]