Toward structural elucidation of the gamma-secretase complex.
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC2661031 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
Toward structural elucidation of the gamma-secretase complex.
Li Huilin H Wolfe Michael S MS Selkoe Dennis J DJ
Structure (London, England : 1993) 20090301 3
Gamma-Secretase is an intramembrane protease complex that mediates the Notch signaling pathway and the production of amyloid beta-proteins. As such, this enzyme has emerged as an important target for development of novel therapeutics for Alzheimer disease and cancer. Great progress has been made in the identification and characterization of the membrane complex and its biological functions. One major challenge now is to illuminate the structure of this fascinating and important protease at atomi ...[more]
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