Ontology highlight
ABSTRACT:
SUBMITTER: Sun L
PROVIDER: S-EPMC4434707 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Sun Linfeng L Zhao Lingyun L Yang Guanghui G Yan Chuangye C Zhou Rui R Zhou Xiaoyuan X Xie Tian T Zhao Yanyu Y Wu Shenjie S Li Xueming X Shi Yigong Y
Proceedings of the National Academy of Sciences of the United States of America 20150427 19
The four-component intramembrane protease γ-secretase is intricately linked to the development of Alzheimer's disease. Despite recent structural advances, the transmembrane segments (TMs) of γ-secretase remain to be specifically assigned. Here we report a 3D structure of human γ-secretase at 4.32-Å resolution, determined by single-particle, electron cryomicroscopy in the presence of digitonin and with a T4 lysozyme fused to the amino terminus of presenilin 1 (PS1). The overall structure of this ...[more]