Ontology highlight
ABSTRACT:
SUBMITTER: Li YJ
PROVIDER: S-EPMC2661402 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Li Ya-Jun YJ Wei Yu-Sheng YS Fu Xiang-Hui XH Hao De-Long DL Xue Zheng Z Gong Huan H Zhang Zhu-Qin ZQ Liu De-Pei DP Liang Chih-Chuan CC
The Journal of biological chemistry 20080804 42
The apolipoprotein (apo) AI/CIII/AIV/AV cluster genes are expressed at different levels in the liver and intestine. The apoCIII enhancer, a common regulatory element, regulates the tissue-specific expression of apoAI, apoCIII, and apoAIV but not apoAV. To study this regulation at the chromatin level, the histone modifications and intergenic transcription in the human apoAI/CIII/AIV/AV cluster were investigated in HepG2 and Caco-2 cells and in the livers of transgenic mice carrying the human gene ...[more]