Imaging apolipoprotein AI in vivo.
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ABSTRACT:
SUBMITTER: Sriram R
PROVIDER: S-EPMC3726305 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Imaging apolipoprotein AI in vivo.
Sriram Renuka R Lagerstedt Jens O JO Petrlova Jitka J Samardzic Haris H Kreutzer Ulrike U Xie Hongtao H Kaysen George A GA Desreux Jean F JF Thonon David D Jacques Vincent V Van Loan Martha M Rutledge John C JC Oda Michael N MN Voss John C JC Jue Thomas T
NMR in biomedicine 20110124 7
Coronary disease risk increases inversely with high-density lipoprotein (HDL) level. The measurement of the biodistribution and clearance of HDL in vivo, however, has posed a technical challenge. This study presents an approach to the development of a lipoprotein MRI agent by linking gadolinium methanethiosulfonate (Gd[MTS-ADO3A]) to a selective cysteine mutation in position 55 of apo AI, the major protein of HDL. The contrast agent targets both liver and kidney, the sites of HDL catabolism, whe ...[more]
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