MARveling at parasite invasion.
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ABSTRACT:
SUBMITTER: Hager KM
PROVIDER: S-EPMC2662992 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Publications
MARveling at parasite invasion.
Hager Kristin M KM Carruthers Vern B VB
Trends in parasitology 20080118 2
Micronemal proteins (MICs) are key mediators of cytoadherence and invasion for Toxoplasma gondii. Emerging evidence indicates that carbohydrate binding facilitates Toxoplasma entry into host cells. The recently solved Toxoplasma MIC1s (TgMIC1s) structure reveals the presence of novel specialized domains that can discriminate between glycan residues. Comparison with Plasmodium erythrocyte-binding antigen 175 reveals that terminal sialic acid residues might represent a shared but tailored invasion ...[more]
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