Ontology highlight
ABSTRACT:
SUBMITTER: Yogalingam G
PROVIDER: S-EPMC2664108 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Yogalingam Gouri G Bonten Erik J EJ van de Vlekkert Diantha D Hu Huimin H Moshiach Simon S Connell Samuel A SA d'Azzo Alessandra A
Developmental cell 20080701 1
Lysosomal exocytosis is a Ca2+-regulated mechanism that involves proteins responsible for cytoskeletal attachment and fusion of lysosomes with the plasma membrane. However, whether luminal lysosomal enzymes contribute to this process remains unknown. Here we show that neuraminidase NEU1 negatively regulates lysosomal exocytosis in hematopoietic cells by processing the sialic acids on the lysosomal membrane protein LAMP-1. In macrophages from NEU1-deficient mice, a model of the disease sialidosis ...[more]