Ontology highlight
ABSTRACT:
SUBMITTER: Bukiya AN
PROVIDER: S-EPMC2665905 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
FEBS letters 20080131 5
Bile acids and other steroids modify large conductance, calcium- and voltage-gated potassium (BK) channel activity contributing to non-genomic modulation of myogenic tone. Accessory BK beta(1) subunits are necessary for lithocholate (LC) to activate BK channels and vasodilate. The protein regions that sense steroid action, however, remain unknown. Using recombinant channels in 1-palmitoyl-2-oleoyl-phosphatidylethanolamine/1-palmitoyl-2-oleoyl-phosphatidylserine bilayers we now demonstrate that c ...[more]