Ontology highlight
ABSTRACT:
SUBMITTER: Treptow W
PROVIDER: S-EPMC2668160 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Treptow Werner W Tarek Mounir M Klein Michael L ML
Journal of the American Chemical Society 20090201 6
Early transition events of the voltage sensor (VS) of Kv1.2 potassium channel embedded in a lipid membrane are triggered using full atomistic molecular dynamics (MD) simulations. When subject to an applied hyperpolarized transmembrane (TM) voltage, the VS undergoes conformational changes and reaches a stable kinetic intermediate state, beta', within 20 ns. The gating charge ( approximately 2e) associated with this fast transition results mainly from salt-bridge rearrangements involving negative ...[more]