Ontology highlight
ABSTRACT:
SUBMITTER: Noh JY
PROVIDER: S-EPMC2670137 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Noh Jee-Yeon JY Lee Huikyong H Song Sungmin S Kim Nam Soon NS Im Wooseok W Kim Manho M Seo Hyemyung H Chung Chul-Woong CW Chang Jae-Woong JW Ferrante Robert J RJ Yoo Young-Jun YJ Ryu Hoon H Jung Yong-Keun YK
The Journal of biological chemistry 20090224 17
Accumulation of expanded polyglutamine proteins is considered to be a major pathogenic biomarker of Huntington disease. We isolated SCAMP5 as a novel regulator of cellular accumulation of expanded polyglutamine track protein using cell-based aggregation assays. Ectopic expression of SCAMP5 augments the formation of ubiquitin-positive and detergent-resistant aggregates of mutant huntingtin (mtHTT). Expression of SCAMP5 is markedly increased in the striatum of Huntington disease patients and is in ...[more]