Ontology highlight
ABSTRACT:
SUBMITTER: Cuesta AM
PROVIDER: S-EPMC2670539 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Cuesta Angel M AM Sánchez-Martín David D Sanz Laura L Bonet Jaume J Compte Marta M Kremer Leonor L Blanco Francisco J FJ Oliva Baldomero B Alvarez-Vallina Luis L
PloS one 20090429 4
There is an urgent need to develop new and effective agents for cancer targeting. In this work, a multivalent antibody is characterized in vivo in living animals. The antibody, termed "trimerbody", comprises a single-chain antibody (scFv) fragment connected to the N-terminal trimerization subdomain of collagen XVIII NC1 by a flexible linker. As indicated by computer graphic modeling, the trimerbody has a tripod-shaped structure with three highly flexible scFv heads radially outward oriented. Tri ...[more]