Ontology highlight
ABSTRACT:
SUBMITTER: Chen F
PROVIDER: S-EPMC6175906 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Chen Feng F Ma Kai K Madajewski Brian B Zhuang Li L Zhang Li L Rickert Keith K Marelli Marcello M Yoo Barney B Turker Melik Z MZ Overholtzer Michael M Quinn Thomas P TP Gonen Mithat M Zanzonico Pat P Tuesca Anthony A Bowen Michael A MA Norton Larry L Subramony J Anand JA Wiesner Ulrich U Bradbury Michelle S MS
Nature communications 20181008 1
Controlling the biodistribution of nanoparticles upon intravenous injection is the key to achieving target specificity. One of the impediments in nanoparticle-based tumor targeting is the inability to limit the trafficking of nanoparticles to liver and other organs leading to smaller accumulated amounts in tumor tissues, particularly via passive targeting. Here we overcome both these challenges by designing nanoparticles that combine the specificity of antibodies with favorable particle biodistr ...[more]