Ontology highlight
ABSTRACT:
SUBMITTER: Tavare R
PROVIDER: S-EPMC3903195 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Tavaré Richard R McCracken Melissa N MN Zettlitz Kirstin A KA Knowles Scott M SM Salazar Felix B FB Olafsen Tove T Witte Owen N ON Wu Anna M AM
Proceedings of the National Academy of Sciences of the United States of America 20140103 3
The noninvasive detection and quantification of CD8(+) T cells in vivo are important for both the detection and staging of CD8(+) lymphomas and for the monitoring of successful cancer immunotherapies, such as adoptive cell transfer and antibody-based immunotherapeutics. Here, antibody fragments are constructed to target murine CD8 to obtain rapid, high-contrast immuno-positron emission tomography (immuno-PET) images for the detection of CD8 expression in vivo. The variable regions of two anti-mu ...[more]