Ontology highlight
ABSTRACT:
SUBMITTER: Clerc J
PROVIDER: S-EPMC2672505 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Clerc Jérôme J Groll Michael M Illich Damir J DJ Bachmann André S AS Huber Robert R Schellenberg Barbara B Dudler Robert R Kaiser Markus M
Proceedings of the National Academy of Sciences of the United States of America 20090409 16
Syrbactins, a family of natural products belonging either to the syringolin or glidobactin class, are highly potent proteasome inhibitors. Although sharing similar structural features, they differ in their macrocyclic lactam core structure and exocyclic side chain. These structural variations critically influence inhibitory potency and proteasome subsite selectivity. Here, we describe the total synthesis of syringolin A and B, which together with enzyme kinetic and structural studies, allowed us ...[more]