Ontology highlight
ABSTRACT:
SUBMITTER: Selimi F
PROVIDER: S-EPMC2672601 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
PLoS biology 20090401 4
Precise neuronal networks underlie normal brain function and require distinct classes of synaptic connections. Although it has been shown that certain individual proteins can localize to different classes of synapses, the biochemical composition of specific synapse types is not known. Here, we have used a combination of genetically engineered mice, affinity purification, and mass spectrometry to profile proteins at parallel fiber/Purkinje cell synapses. We identify approximately 60 candidate pos ...[more]