Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh S
PROVIDER: S-EPMC26760 | biostudies-literature | 1999 Mar
REPOSITORIES: biostudies-literature
Ghosh S S Watanabe R M RM Hauser E R ER Valle T T Magnuson V L VL Erdos M R MR Langefeld C D CD Balow J J Ally D S DS Kohtamaki K K Chines P P Birznieks G G Kaleta H S HS Musick A A Te C C Tannenbaum J J Eldridge W W Shapiro S S Martin C C Witt A A So A A Chang J J Shurtleff B B Porter R R Kudelko K K Unni A A Segal L L Sharaf R R Blaschak-Harvan J J Eriksson J J Tenkula T T Vidgren G G Ehnholm C C Tuomilehto-Wolf E E Hagopian W W Buchanan T A TA Tuomilehto J J Bergman R N RN Collins F S FS Boehnke M M
Proceedings of the National Academy of Sciences of the United States of America 19990301 5
We are conducting a genome scan at an average resolution of 10 centimorgans (cM) for type 2 diabetes susceptibility genes in 716 affected sib pairs from 477 Finnish families. To date, our best evidence for linkage is on chromosome 20 with potentially separable peaks located on both the long and short arms. The unweighted multipoint maximum logarithm of odds score (MLS) was 3.08 on 20p (location, chi = 19.5 cM) under an additive model, whereas the weighted MLS was 2.06 on 20q (chi = 57 cM, recurr ...[more]