Ontology highlight
ABSTRACT:
SUBMITTER: Hu G
PROVIDER: S-EPMC2676231 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Hu Guohong G Chong Robert A RA Yang Qifeng Q Wei Yong Y Blanco Mario A MA Li Feng F Reiss Michael M Au Jessie L-S JL Haffty Bruce G BG Kang Yibin Y
Cancer cell 20090101 1
Targeted therapy for metastatic diseases relies on the identification of functionally important metastasis genes from a large number of random genetic alterations. Here we use a computational algorithm to map minimal recurrent genomic alterations associated with poor-prognosis breast cancer. 8q22 genomic gain was identified by this approach and validated in an extensive collection of breast tumor samples. Regional gain of 8q22 elevates expression of the metastasis gene metadherin (MTDH), which i ...[more]