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Total synthesis and absolute configuration of the bisanthraquinone antibiotic BE-43472B.

ABSTRACT: An-T-biotic: The first total synthesis of the T-shaped bisanthraquinone natural product BE-43472B was accomplished and its absolute configuration assigned. Key transformations in the pivotal cascade sequence include a Diels-Alder reaction, a hemiketal formation, and a nucleophilic aromatic ipso substitution.

SUBMITTER: Nicolaou KC

PROVIDER: S-EPMC2678724 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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Total synthesis and absolute configuration of the bisanthraquinone antibiotic BE-43472B.

Nicolaou K C KC Lim Yee Hwee YH Becker Jochen J

Angewandte Chemie (International ed. in English) 20090101 19

An-T-biotic: The first total synthesis of the T-shaped bisanthraquinone natural product BE-43472B was accomplished and its absolute configuration assigned. Key transformations in the pivotal cascade sequence include a Diels-Alder reaction, a hemiketal formation, and a nucleophilic aromatic ipso substitution. ...[more]

PMID: 19235819

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